SUMA (PFAFFIA PANICULATA)
Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model
1: Cancer Lett. 2005 Aug 26;226(2):107-13. Epub 2004 Dec 28
Inhibitory effects of Pfaffia paniculata (Brazilian ginseng) on preneoplastic and neoplastic lesions in a mouse hepatocarcinogenesis model.
- da Silva TC, Paula da Silva A, Akisue G, Luis Avanzo J, Kazumi Nagamine M, Fukumasu H, Matsuzaki P, Cesar Raspantini P, Haraguchi M,
- Lima Gorniak S, Dagli ML.
Department of Pathology, Faculty of Veterinary Medicine and Zootechny, University of Sao Paulo, Av. Prof. Dr Orlando Marques de Paiva, 87, CEP 05508-900 Sao Paulo, SP, Brazil.
Studies have been demonstrating Pfaffia paniculata root (Brazilian ginseng) anticarcinogenic activities. We evaluated its chemopreventive effects on preneoplastic hepatic lesions. BALB/c aged-15 days received 10mug/g of diethylnitrosamine carcinogen, i.p. They were fed with the powdered root added to the diet: 0.5, 2 or 10% during 27 weeks. After being sacrificed, the macroscopic lesions in the livers were examined. Preneoplastic or neoplastic lesions were measured, quantified and classified morphologically. The treatment reduced the incidence, mean area and number of lesions, indicating an inhibitory effect of these roots on hepatocarcinogenesis promotion or progression steps.
PMID: 16039950 [PubMed - indexed for MEDLINE]
Pfaffia paniculata-induced changes in plasma estradiol-17beta, progesterone and testosterone levels in mice
1: J Reprod Dev. 2003 Apr;49(2):175-80.
Pfaffia paniculata-induced changes in plasma estradiol-17beta, progesterone and testosterone levels in mice.
Graduate School of Medical Imaging, Suzuka University of Medical Science, 1001-1 Kishioka-cho, Suzuka-shi, Mie 510-0293, Japan.
The present study undertook chemical analysis of components of Pfaffia paniculata roots. In addition, an animal experiment was conducted in which mice had ad libitum access to water enriched with powdered P. paniculata root for 30 days. Changes in plasma concentrations of estradiol-17beta and progesterone in female mice and of testosterone in male mice were ascertained. The results revealed that P. paniculata roots contain two types of phytosteroids, beta-sitosterol and stigmasterol, in addition to other compounds such as pfaffic acid, allantoin, saponins, beta-sitosteryl-beta-D-glucoside, and stigmasteryl-beta-D-glucoside. Regarding changes in plasma concentrations of hormones, levels of the sex hormones estradiol-17beta, progesterone and testosterone were clearly higher for mice that drank P. paniculata root-enriched water than for mice that drank plain water. Powdered P. paniculata root is easily dissolved in feed or water, and as no adverse reactions were seen in mice within 30 days of oral intake, consumption of P. paniculata for long periods of time appears safe.
PMID: 14967943 [PubMed - indexed for MEDLINE]
